Short stereoselective synthesis of the Phytophthora universal mating hormone α1 using lithiation/borylation reactions.
نویسندگان
چکیده
The universal mating hormone α 1 of the virulent plant pathogen Phytophthora has been synthesized in 12 steps and 28 % overall yield. Key CC bond-forming steps involved the use of two lithiation/borylation reactions to couple together enantioenriched building blocks, one of which also set up the stereochemistry of the tertiary alcohol at C11. Detailed analysis showed that the diastereomeric purity of the target molecule was >91 %, the highest obtained to date.
منابع مشابه
Short Stereoselective Synthesis of the Phytophthora Universal Mating Hormone Alpha 1 using Lithiation/Borylation Reactions**
Alpha 1, the universal mating hormone of the virulent plant pathogen, Phytophthora, has been synthesized in 12 steps and 28% overall yield. Key C-C bond forming steps involved the use of two lithiation/borylation reactions to couple together enantioenriched building blocks, one of which also set up the stereochemistry at C11. Detailed analysis showed that the diastereomeric purity of the target...
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 53 17 شماره
صفحات -
تاریخ انتشار 2014